A Network-Based Approach to Cell Metabolism : From Structure to Flux Balances
Softcover reprint of the original 1st ed. 2017
by
Oriol Guell
Book Details
Format
Paperback / Softback
Book Series
Springer Theses
ISBN-10
3319876953
ISBN-13
9783319876955
Edition
Softcover reprint of the original 1st ed. 2017
Publisher
Springer International Publishing AG
Imprint
Springer International Publishing AG
Country of Manufacture
GB
Country of Publication
GB
Publication Date
Aug 11th, 2018
Print length
151 Pages
Ksh 16,200.00
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They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions.Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks.
This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures. The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions. Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspects of the networks themselves to the balance of biochemical fluxes.
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