Antisense Therapeutics

A timely primer on the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery.

Part I. Introduction Antisense Therapeutics: A Promise Waiting to be Fulfilled M. Ian Phillips Antisense Inhibition: Oligonucleotides, Ribozymes, and siRNAs Y. Clare Zhang, Meghan M. Taylor, Willis K. Samson, and M. Ian Phillips Part II. Cardiovascular Local Application of Antisense for Prevention of Restenosis Patrick L. Iversen, Nicholas Kipshidze, Jeffrey W. Moses, and Martin B. Leon Antisense Therapeutics for Hypertension: Targeting the Renin-Angiotensin System M. Ian Phillips and Birgitta Kimura Antisense Strategies for the Treatment of Heart Failure Sian E. Harding, Federica del Monte, and Roger J. Hajjar Part III. Cancer Clinical Studies of Antisense Oligonucleotides for Cancer Therapy Rosanne M. Orr and F. Andrew Dorr Antisense Therapy in Clinical Oncology: Preclinical and Clinical Experiences Ingo Tamm Radionuclide-Peptide Nucleic Acid Diagnosis and Treatment of Pancreatic Cancer Eric Wickstrom, Xiaobing Tian, Nariman V. Amirkhanov, Atis Chakrabarti, Mohan R. Aruva, Ponugoti S. Rao, Wenyi Qin, Weizhu Zhu, Edward R. Sauter, and Mathew L. Thakur Suppression of Pancreatic and Colon Cancer Cells by Antisense K-ras RNA Expression Vectors Kazunori Aoki, Shumpei Ohnami, and Teruhiko Yoshida Induction of Tumor Cell Apoptosis and Chemosensitization by Antisense Strategies Manuel Rieber and Mary Strasberg-Rieber Utility of Antioncogene Ribozymes and Antisense Oligonucleotides in Reversing Drug Resistance Tadao Funato Part IV. Blood-Brain Barrier Transport of Antisense Across the Blood-Brain Barrier Laura B. Jaeger and William A. Banks Part V. Dermal Transdermal Delivery of Antisense Oligonucletoides Rhonda M. Brand and Patrick L. Iversen Part VI. Drugs Antisense Strategies for Redirection of Drug Metabolism: Using Paclitaxel as a Model Vikram Arora Part VII. Gastrointestinal Antisense Oligonucleotide Treatment of Inflammatory Bowel Diseases Bruce R. Yacyshyn Part VIII. Hepatitis Optimizing Electroporation Conditions for the Intracellular Delivery of Morpholino Antisense Oligonucleotides Directed Against the Hepatitis C Virus Internal Ribosome Entry Site Ronald Jubin Index