Bile Acids and Their Receptors
1st ed. 2019
Book Details
Format
Paperback / Softback
Book Series
Handbook of Experimental Pharmacology
ISBN-10
3030220079
ISBN-13
9783030220075
Edition
1st ed. 2019
Publisher
Springer Nature Switzerland AG
Imprint
Springer Nature Switzerland AG
Country of Manufacture
GB
Country of Publication
GB
Publication Date
Sep 19th, 2020
Print length
378 Pages
Product Classification:
PhysiologyEndocrinologyGastroenterologyHepatologyPharmacology
Ksh 18,000.00
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This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target.
This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR and GPBAR1 are essential bile acid sensors that integrate the de novo bile acid synthesis with intestinal microbiota and liver metabolism, in a broader sense, BARs play a pathogenic role in the development of common human alignments including liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis.
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