Brain Energy Metabolism in Alzheimers Disease - Part B

Brain Energy Metabolism in Alzheimer’s Disease – Part B, Volume 187 in the International Review of Neurobiology series, presents current advances and comprehensive reviews on metabolic dysfunction in neurodegenerative diseases. This volume brings together contributions from an international panel of experts, focusing on the molecular and cellular mechanisms underlying energy imbalance in Alzheimer’s disease and related disorders. Chapters in this release explore key processes such as autophagy and ESCRT pathways, tau modifications, insulin resistance, and mitochondrial dysfunction. Additional sections examine neurovascular–glial interactions, genetic and epigenetic factors in neurodegeneration, and the roles of metallospecies, noncoding RNAs, and phase separation in disease progression. Further contributions address neuroprotective signaling pathways, metabolic impairments in glucose and lipid homeostasis, and emerging diagnostic and therapeutic approaches, including liquid biopsy markers and targeted metabolic interventions. Together, these chapters provide an integrated overview of the mechanisms, biomarkers, and therapeutic opportunities associated with brain energy metabolism in neurodegenerative diseases, making this volume an essential reference for researchers and clinicians in neuroscience and neurobiology.