Calcitonin Gene-Related Peptide (CGRP) Mechanisms : Focus on Migraine
1st ed. 2019
Book Details
Format
Paperback / Softback
Book Series
Handbook of Experimental Pharmacology
ISBN-10
3030214567
ISBN-13
9783030214562
Edition
1st ed. 2019
Publisher
Springer Nature Switzerland AG
Imprint
Springer Nature Switzerland AG
Country of Manufacture
GB
Country of Publication
GB
Publication Date
Sep 11th, 2020
Print length
192 Pages
Product Classification:
Neurology & clinical neurophysiologyPain & pain managementPharmacologyNeurosciences
Ksh 16,200.00
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Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention.
This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention.
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