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Calcitonin Gene-Related Peptide (CGRP) Mechanisms : Focus on Migraine - 1st ed. 2019

By: (Edited by) Pierangelo Geppetti , (Edited by) Susan D. Brain

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Ksh 16,200.00

Format: Paperback / Softback

ISBN-10: 3030214567

ISBN-13: 9783030214562

Edition: 1st ed. 2019

Series: Handbook of Experimental Pharmacology

Publisher: Springer Nature Switzerland AG

Imprint: Springer Nature Switzerland AG

Country of Manufacture: GB

Country of Publication: GB

Publication Date: Sep 11th, 2020

Print length: 192 Pages

Product Classification: Neurology & clinical neurophysiology
Pain & pain management
Pharmacology
Neurosciences

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Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention.
This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine.  The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention. 

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