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Cardiovascular Safety in Drug Development and Therapeutic Use : New Methodologies and Evolving Regulatory Landscapes - Softcover reprint of the original 1st ed. 2017

By: (Author) Dilip R. Karnad , (Author) J. Rick Turner , (Author) Snehal Kothari

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Ksh 10,800.00

Format: Paperback / Softback

ISBN-10: 3319820850

ISBN-13: 9783319820859

Edition: Softcover reprint of the original 1st ed. 2017

Publisher: Springer International Publishing AG

Imprint: Adis

Country of Manufacture: GB

Country of Publication: GB

Publication Date: Jun 12th, 2018

Print length: 342 Pages

Product Classification: Cardiovascular medicine
Pharmacology

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At a time when the field of cardiac safety is going through important changes, this unique book provides the rationale for, and cutting-edge explanations of, new regulatory landscapes that will likely govern cardiac safety assessments globally for the foreseeable future.

At a time when the field of cardiac safety is going through important changes, this unique book provides the rationale for, and cutting-edge explanations of, new regulatory landscapes that will likely govern cardiac safety assessments globally for the foreseeable future.  Exposure-response modeling is already being accepted by regulatory agencies in lieu of the traditional Thorough QT/QTc Study, and the Comprehensive in vitro Proarrhythmia Assay initiative is well under way.

Developments in the field of cardiovascular safety are also described and discussed in the book.  These include the search for more efficient ways to exonerate new drugs for type 2 diabetes from an unacceptable cardiovascular liability, how best to address off-target blood pressure increases induced by noncardiovascular drugs, and the continued evolution of the discipline of Cardio-oncology.


“a resource that will likely serve as a standard for years to come” 

- Dr Jonathan Seltzer

Therapeutic Innovation & Regulatory Science, 2017;51(2):180


“I have no hesitation in recommending this book as a valuable reference source” 

- Dr Rashmi Shah

Journal for Clinical Studies, 2017;9(1):62-63




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