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Chemistry and Molecular Aspects of Drug Design and Action
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Chemistry and Molecular Aspects of Drug Design and Action

Book Details

Format Paperback / Softback
ISBN-10 0367387360
ISBN-13 9780367387365
Publisher Taylor & Francis Ltd
Imprint CRC Press
Country of Manufacture GB
Country of Publication GB
Publication Date Sep 19th, 2019
Print length 384 Pages
Weight 453 grams
Product Classification: PharmacologyPharmaceutical technology
Ksh 12,250.00
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Drawn from the work of world-renowned pharmacochemistry scientists, this book explores research that defines the emergence of rational drug design. Offering insight from their own specialized subjects, these pioneers highlight the variety of approaches being employed in this field, including those that start by considering either molecular mechanisms of drug action, or the metabolizing enzyme action occurring in the structure of a drug molecule. Another approach they explore is one that starts from the pathobiochemistry and pathophysiology of target diseases. Furthermore, the book also considers drug development that makes use of already developed compounds stored in data banks.
An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to develop pharmacophores, and further optimization to produce the best compounds.

Chemistry and Molecular Aspects of Drug Design and Action brings together an impressive collection of world-renowned pharmacochemistry scientists who are currently defining the emergence of rational drug design. Offering insight from their own specialized research, these pioneers highlight the variety of approaches being employed in this field, including those that start by considering either molecular mechanisms of drug action, or the metabolizing enzyme action occurring in the structure of a drug molecule. Another approach they explore is one that starts from the pathobiochemistry and pathophysiology of target diseases. Furthermore, the book also considers drug development that makes use of already developed compounds stored in data banks.

Divided into five parts, each dedicated to various aspects of the classical medicinal chemistry approach, the text makes it easy for readers to focus on a field of specific interest.

  • Chemical, Biochemical, and Biological Aspects of Pathophysiological Conditions
  • Classical Medicinal Chemistry
  • Drug Design, Chemical and Molecular Aspects of Drug Action
  • Drug Xenobiotic Metabolism
  • Physical Organic and Theoretical Medicinal Chemistry
  • While each section can be studied independently, the combined material in this volume provides the most comprehensive overview available on rational drug design. This work is an invaluable resource both for those entering the field, as well as those researchers looking to b


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