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Coarse-Grained Modeling of Biomolecules
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Coarse-Grained Modeling of Biomolecules

Book Details

Format Hardback or Cased Book
ISBN-10 1466576065
ISBN-13 9781466576063
Publisher Taylor & Francis Inc
Imprint CRC Press Inc
Country of Manufacture GB
Country of Publication GB
Publication Date Oct 30th, 2017
Print length 430 Pages
Weight 1,108 grams
Dimensions 16.00 x 24.10 x 3.40 cms
Ksh 36,000.00
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This book reflects on the tremendous impact of computational modeling, focusing on coarse-grained simulations for biomolecules, such as proteins and nucleic acids, for which systems may be too large and the processes too slow for atomistic or quantum simulations.

"The chapters in this book survey the progress in simulating biomolecular dynamics…. The images conjured up by this work are not yet universally loved, but are beginning to bring new insights into the study of biological structure and function. The future will decide whether this scientific movement can bring forth its Picasso or Modigliani." –from the Foreword by Peter G. Wolynes, Bullard-Welch Foundation Professor of Science, Rice University

This book highlights the state-of-art in coarse-grained modeling of biomolecules, covering both fundamentals as well as various cutting edge applications. Coarse-graining of biomolecules is an area of rapid advances, with numerous new force fields having appeared recently and significant progress made in developing a systematic theory of coarse-graining. The contents start with first fundamental principles based on physics, then survey specific state-of-art coarse-grained force fields of proteins and nucleic acids, and provide examples of exciting biological problems that are at large scale, and hence, only amenable to coarse-grained modeling.

  • Introduces coarse-grained models of proteins and nucleic acids.
  • Showcases applications such as genome packaging in nuclei and understanding ribosome dynamics
  • Gives the physical foundations of coarse-graining
    • Demonstrates use of models for large-scale assemblies in modern studies
  • Garegin A. Papoian

    is the first Monroe Martin Associate Professor with appointments in the Department of Chemistry and Biochemistry and the Institute for Physical Science and Technology at the University of Maryland.


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