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Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C-H Bonds
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Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C-H Bonds

Softcover reprint of the original 1st ed. 2016

Book Details

Format Paperback / Softback
Book Series Springer Theses
ISBN-10 3319817671
ISBN-13 9783319817675
Edition Softcover reprint of the original 1st ed. 2016
Publisher Springer International Publishing AG
Imprint Springer International Publishing AG
Country of Manufacture GB
Country of Publication GB
Publication Date Apr 22nd, 2018
Print length 144 Pages
Ksh 16,200.00
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This thesis reports the latest developments in the direct amination of various C-H bonds using an H-Zn exchange/electrophilic amination strategy.

This thesis reports the latest developments in the direct amination of various C-H bonds using an H-Zn exchange/electrophilic amination strategy.  McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.

The material outlined in this book shows how McDonald achieved C-H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.

McDonald''s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. 


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