This book provides an overview of some neurological and psychiatric conditions in which brain oscillations play a role, epilepsy being the prime example. It then analyzes the detailed mechanisms of the relevant oscillations, as elucidated by in vitro and modeling studies. Gap junctions play a surprisingly critical part.
This book first reviews the case that brain oscillations not only are important for cognition, as long suspected, but also play a part in the expression of signs and symptoms of neuropsychiatric disorders. The cellular mechanisms of many of the clinically relevant oscillations have been studied by the authors and their colleagues, using in vitro slice methods as well as detailed computer simulations. A surprising insight is that gap junctions between principal neurons play an absolutely critical role in so many types of oscillation in neuronal populations; oscillations are not just the result of properties of individual neurons and their synaptic connections. Furthermore, the way in which gap junctions produce oscillations in the cortex is novel, involving as it does global properties of networks, rather than just the time constants of membrane currents. This insight has implications for therapeutics as well as for our understanding of normal brain functions.
Get Cortical Oscillations in Health and Disease by at the best price and quality guranteed only at Werezi Africa largest book ecommerce store. The book was published by Oxford University Press Inc and it has pages. Enjoy Shopping Best Offers & Deals on books Online from Werezi - Receive at your doorstep - Fast Delivery - Secure mode of Payment
