Creatine : From Basic Science to Clinical Application

This volume, based on the International Congress Creatine: From Basic Science to Clinical Application, held in Milan on June 4, 1999, outlines the physiological role of creatine in the human body as well as its possible role in different pathological conditions.

Preface. List of Contributors. I: Creatine: Biochemical Aspects. Creatine-Phosphocreatine Pathway in the Intracellular Networks of Energy Transfer and Signal Transduction in Muscle Cells; V. Saks, et al. Guanidinoacetate Methyltransferase (GAMT) Deficiency, the First Inborn Error of Creatine Metabolism; S. Stöckler-Ipsiroglu. II: Physiology and Physiopathology. A Physiological View of The Creatine-Phosphate Shuttle, Exercise, and Protein Synthesis; S.P. Bessman, J. Luo. Creatine in Cardiovascular Metabolism During Physiological and Pathological Conditions: NMR Studies; J.F. Clark. III: Role of Creatine in the Clinical Practice. Effects and Safety of Dietary and Supplementary Creatine; R.C. Harris. Creatine Supplementation in Patients with Chronic Heart Failure; A. Gordon. Creatine in Sports Medicine: Nutritional Supplementation and/or Medicinal Product? G. Benzi. IV: Use of Creatine in Sports Medicine. Physiological Role of Creatine in Muscle Metabolism During Exercise; P. Ruggeri. Impact of Oral Creatine Supplementation on Muscle Performance During Training and Rehabilitation; P. Hespel, et al. Factors Modifying Creatine Accumulation in Human Skeletal Muscle; P.L. Greenhaff. V: Use of Creatine: New Potential Applications. New Areas for Creatine Supplementation: Chronic Obstructive Pulmonary Disease and Geriatric Conditions; G. Enzi. Creatine Supplementation in Mitochondrial Cytopathies; J.M. Bourgeois, M.A. Tarnopolsky. The Neuroprotective Properties of Creatine in Animal Models of Neurodegenerative Diseases; R. Kaddurah-Daouk, et al.