Dermatokinetics of Therapeutic Agents

Presenting the first comprehensive reference on this important new area of research, this book provides an overview of the fundamentals of dermatokinetics: the study of drug uptake into skin layers. It offers a detailed discussion of dermatokinetics that is applicable to any route of administration and to different pharmaceutical drug delivery systems. The author includes a general overview of the theoretical as well as the practical aspects of dermatokinetics and addresses the impact of drug delivery system design on the dermatokinetics of drugs. Chapters cover such topics as dermatopharmacology, cutaneous microdialysis, and dermatokinetics of gene therapeutics.

Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, allows certain topically applied substances and toxins to pass. The dermatokinetics of a drug determines the efficacy of treatment of skin disorders.

Presenting the first comprehensive reference on this important area of research, Dermatokinetics of Therapeutic Agents includes a general overview of the theoretical as well as practical aspects of dermatokinetics and addresses the impact of a drug delivery system on the dermatokinetics of drugs. Chapters and illustrations cover introductory aspects and the significance, methods, and models used in dermatokinetic studies of therapeutic agents.

Topics include:

• Theoretical Models for Dermatokinetics of Therapeutic Agents
• Drug Delivery Approaches to Modulate Dermatokinetics of Drugs
• Conventional Methods of Cutaneous Drug Sampling
• Cutaneous Microdialysis
• Sampling Substrates by Skin Permeabilization
• Spectroscopic Techniques in Dermatokinetics Studies
• Regulatory Perspective of Dermatokinetic Studies