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Dna Polymerases: Discovery, Characterization And Functions In Cellular Dna Transactions

By: (Author) Giovanni Maga , (Author) Giuseppe Villani , (Author) Silvio Spadari , (Author) Ulrich Hubscher

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Ksh 19,450.00

Format: Hardback or Cased Book

ISBN-10: 9814299162

ISBN-13: 9789814299169

Publisher: World Scientific Publishing Co Pte Ltd

Imprint: World Scientific Publishing Co Pte Ltd

Country of Manufacture: SG

Country of Publication: GB

Publication Date: Apr 15th, 2010

Print length: 340 Pages

Weight: 778 grams

Dimensions (height x width x thickness): 25.30 x 17.00 x 2.00 cms

Product Classification: DNA & Genome

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Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex physiological processes of DNA replication and repair. This book summarizes the knowledge of these enzymes in viruses, bacteria, archaea and eukaryotes.
Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, genome sequencing, nucleic acids-based diagnostics and in techniques to analyze ancient and otherwise damaged DNA. Moreover, some diseases are related to DNA polymerase defects, and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. We have recently witnessed the discovery of an abundance of novel DNA polymerases in viruses, bacteria, archaea and eukaryotes with specialized properties whose physiological functions are only beginning to be understood. This book summarizes the current knowledge of these fascinating enzymes. It is intended for a wide audience from basic scientists, to diagnostic laboratories and to clinicians who seek a better understanding of these fascinating enzymes.

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