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Drug Research and Development for Adults Across the Older Age Span : Proceedings of a Workshop

By: (Author) Board on Health Care Services , (Author) Board on Health Sciences Policy , (Author) and Translation Forum on Drug Discovery Development , (Author) and Independence Forum on Aging Disability , (Author) and Medicine National Academies of Sciences Engineering , (Author) Health and Medicine Division , (Author) National Cancer Policy Forum , (Edited by) Carolyn Shore , (Edited by) Erin Hammers Forstag

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Ksh 7,200.00

Format: Paperback / Softback

ISBN-10: 0309685680

ISBN-13: 9780309685689

Publisher: National Academies Press

Imprint: National Academies Press

Country of Manufacture: GB

Country of Publication: GB

Publication Date: Jan 29th, 2022

Print length: 142 Pages

Product Classification: Geriatric medicine

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There is a void in evidence-based information for making informed decisions on how to optimize care for older adults, particularly those 80 years and over. Because older adults are vastly underrepresented in clinical trials, there is a dearth of information about the appropriate use of drugs in this population. Yet older adults have higher rates of comorbidities and simultaneous use of multiple medications than the general population, and are the majority users of many medications. Additionally, age-related physiological and pathological changes, particularly for adults 80 years of age and older, can lead to significant differences in the pharmacokinetics (PK)2 and pharmacodynamics (PD)3 of a given drug compared to the general population. On August 5 and 6, 2020, the National Academies of Sciences, Engineering, and Medicine hosted a workshop titled Drug Research and Development for Adults Across the Older Age Span. The workshop was designed to examine the challenges and opportunities in drug research and development for older adult populations, explore barriers that impede safety and efficacy studies in these populations, and share lessons learned for better understanding clinical pharmacology for populations over age 65. This publication summarizes the presentation and discussion of the workshop. Table of ContentsFront Matter1 Introduction2 Inclusion of Older Adults in Clinical Trials: An Evolving Landscape3 Overcoming Key Barriers4 Alternative Study Approaches5 Strategies for Engaging Older Adults in Clinical Research6 Clinical Trials in the Era of COVID-19 and Beyond7 Reflections and Key TakeawaysAppendix A: ReferencesAppendix B: Workshop AgendaAppendix C: Speaker Biosketches

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