Dynemicin A, Uncialamycin and Analogues
Book Details
Format
Hardback or Cased Book
ISBN-10
1785481509
ISBN-13
9781785481505
Publisher
ISTE Press Ltd - Elsevier Inc
Imprint
ISTE Press Ltd - Elsevier Inc
Country of Manufacture
NL
Country of Publication
GB
Publication Date
Jun 14th, 2016
Print length
144 Pages
Weight
388 grams
Dimensions
16.10 x 23.80 x 1.40 cms
Product Classification:
Pharmacy / dispensing
Ksh 13,700.00
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Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis.Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs.
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