Epilepsy : Mechanisms, Models, and Translational Perspectives

Written for researchers and clinicians in neurology and neuroscience, this text offers a bridge across the so-called translational divide, to cover innovative treatment strategies that, while based on scientific principles, have yet to be tested rigorously in clinical settings. The text features the contributions of leading researchers in adult and pediatric epilepsy who cover a range of topics including gene therapy, metabolic regulation, and neuroprotective strategies. It offers an understanding of the pathogenesis and mechanisms of various epilepsy syndromes, highlights therapies with the greatest potential, and identifies challenges common to researchers.

Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervous system, have led to a substantial reduction in the morbidity and mortality of patients with epilepsy. At the same time, remarkable developments in neuroscience have enhanced our understanding of brain structure and function.

Epilepsy: Mechanisms, Models, and Translational Perspectives incorporates new translational advances that bring epilepsy therapies from the laboratory bench to the bedside and back again. It brings together the work of more than 70 of the field’s most respected and cutting-edge researchers and clinicians. In 24 chapters, this extraordinarily comprehensive and current work:

Offers an overview of the basic anatomic and functional substrates of seizure genesis and considers novel pathogenic concepts that have both emerged and been validated experimentally

• Examines antiepileptic drug therapy, including the latest on molecular targets



• Looks at the state of surgical treatments for epilepsy and discusses advances in the fields of structural and functional neuroimaging



• Reviews the variety of nontraditional therapeutic options, such as the ketogenic diet, the vagus nerve stimulator, immunomodulators, neurosteroids, herbs, and botanicals



• Investigates neuroendocrine, hormonal, and biobehavioral factors that influence seizure susceptibility—information that can be incorporated into the design of treatment algorithms on an individualized basis



• Provides a glimpse of what future epilepsy therapies might look like, from novel mechanisms of drug delivery to gene and stem-cell therapies for epilepsy to seizure detection meth