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Exploring Novel Clinical Trial Designs for Gene-Based Therapies : Proceedings of a Workshop

By: (Author) Board on Health Sciences Policy , (Author) and Medicine National Academies of Sciences Engineering , (Author) Forum on Regenerative Medicine , (Author) Health and Medicine Division , (Edited by) Joe Alper , (Edited by) Meredith Hackmann , (Edited by) Sarah H. Beachy , (Edited by) Siobhan Addie

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Format: Paperback / Softback

ISBN-10: 0309672988

ISBN-13: 9780309672986

Publisher: National Academies Press

Imprint: National Academies Press

Country of Manufacture: GB

Country of Publication: GB

Publication Date: Aug 27th, 2020

Print length: 126 Pages

Product Classification: Clinical trials
Medical genetics

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Recognizing the potential design complexities and ethical issues associated with clinical trials for gene therapies, the Forum on Regenerative Medicine of the National Academies of Sciences, Engineering, and Medicine held a 1-day workshop in Washington, DC, on November 13, 2019. Speakers at the workshop discussed patient recruitment and selection for gene-based clinical trials, explored how the safety of new therapies is assessed, reviewed the challenges involving dose escalation, and spoke about ethical issues such as informed consent and the role of clinicians in recommending trials as options to their patients. The workshop also included discussions of topics related to gene therapies in the context of other available and potentially curative treatments, such as bone marrow transplantation for hemoglobinopathies. This publication summarizes the presentation and discussion of the workshop. Table of ContentsFront Matter1 Introduction and Overview2 Developing First-in-Human Gene Therapy Clinical Trials3 Understanding the Complexities of Patient Selection, Enrollment, and the Consent Process4 Developing Endpoints for Gene Therapy Clinical Trials5 Integrating Gene-Based Therapies into Clinical Practice: Exploring Long-Term Clinical Follow-Up of Patients6 Reflections on the Workshop and Potential Opportunities for Next StepsReferencesAppendix A: Workshop AgendaAppendix B: Speaker Biographical SketchesAppendix C: Statement of TaskAppendix D: Registered Attendees

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