Fluorouracil : Synthesis, Health Effects & Role in Chemotherapy
Book Details
Format
Hardback or Cased Book
ISBN-10
1620819708
ISBN-13
9781620819708
Publisher
Nova Science Publishers Inc
Imprint
Nova Science Publishers Inc
Country of Manufacture
US
Country of Publication
GB
Publication Date
Oct 9th, 2012
Print length
148 Pages
Weight
360 grams
Dimensions
23.30 x 15.90 x 1.30 cms
Product Classification:
Pharmacology
Ksh 25,550.00
Not available
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The fluoropyrimidine 5-fluorouracil (5-FU), an antimetabolite drug, works by being incorporated in the RNA and DNA and by the inhibition of the nucleotide synthetic enzyme thymidylate synthase. It is widely used in the treatment of a range of cancers, including gastrointestinal, head and neck, and breast cancers. In this book, the authors present current research in the study of the synthesis, health effects and role in chemotherapy of fluorouracil. Topics discussed include the antiproliferative activities, cell-cycle regulation, apoptosis and cellular differentiation of acyclic 5-fluorouracil O, N-Acetals; 5-fluorouracil and its immunotoxicity and side effects; 5-fluorouracil application in the management of bleb failure; and cisplatin and 5-fluorouracil for the treatment of ovarian adenocarcinoma.
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