Folding/Unfolding Kinetics of Lattice Proteins by Applying a Simple Statistical Mechanical Model for Protein Folding
Book Details
Format
Paperback / Softback
ISBN-10
1617619221
ISBN-13
9781617619229
Publisher
Nova Science Publishers Inc
Imprint
Nova Science Publishers Inc
Country of Manufacture
US
Country of Publication
GB
Publication Date
Feb 16th, 2011
Print length
42 Pages
Weight
90 grams
Dimensions
21.10 x 15.30 x 0.50 cms
Product Classification:
Biochemistry
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The folding/unfolding kinetics of a three-dimensional lattice protein was studied using a simple statistical mechanical model for protein folding that was previously developed. The model considers the specificity of an amino acid sequence and the native structure of a given protein. The characteristic relaxation rate on the free energy surface was calculated starting from a completely unfolded structure (or native structure) that is assumed to associate with a folding rate (or an unfolding rate). To elucidate the roles of individual amino acid residues in protein folding/unfolding kinetics, the kinetic properties for all possible single amino acid substitutions of these proteins were calculated and their responses were examined. This book presents and discusses research results in the kinetics of protein folding/unfolding.
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