Fragile Sites : New Discoveries & Changing Perspectives
Book Details
Format
Hardback or Cased Book
ISBN-10
1600215041
ISBN-13
9781600215049
Publisher
Nova Science Publishers Inc
Imprint
Nova Science Publishers Inc
Country of Manufacture
US
Country of Publication
GB
Publication Date
Aug 10th, 2007
Print length
359 Pages
Weight
976 grams
Dimensions
25.90 x 17.90 x 2.80 cms
Product Classification:
Biotechnology
Ksh 29,500.00
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Fragile sites common features of human (and also of other mammalian) chromosomes. Chromosomal fragile sites are non-randomly distributed loci that are especially prone to forming gaps, breaks or tri-radial figures in metaphase chromosomes when cells are cultured under conditions that inhibit DNA replication or repair. This new and important book is divided into 3 parts: 1. An overview about fragile sites on chromosomes, their classification, cytogenetics, expression, replication timing, and clinical significance and heritance, 2. The characteristics of fragile loci which lead to the expression of fragility specifically at these sites and 3. the link between fragile sites and human pathological conditions.
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