Gap Junction Channels and Hemichannels

Gap junction channels are a group of intercellular channels expressed in tissues and organs to synchronize many physiological processes. Pannexin channels are a family of closely related large-pore channels virtually unknown a decade ago. The field of connexin and pannexin research has recently exploded and became one of the most active areas of research. Numerous novel approaches and techniques have been developed, but there is no single book to dedicate on the unique techniques and protocols for the research on these large pore channels. The authors plan a book to focus on recent state-of-the-art techniques and protocols in various aspects of this diverse research field.

Gap junction channels are a group of intercellular channels expressed in tissues and organs to synchronize many physiological processes. A gap junction channel is formed by the docking of two hemichannels, and each hemichannel is a hexamer of connexins. The field of gap junction channel and hemichannel research has recently exploded and became one of the most active areas of cell biology. Numerous novel approaches and techniques have been developed, but there is no single book dedicated to the unique techniques and protocols employed for the research on these large pore channels. This book fills the gap and focuses on protocols, approaches and reviews of gap junction channels and connexin hemichannels. It will be a useful reference for graduate students, postdoctoral fellows and researchers. Anyone with an interest in gap junction channels and hemichannels will need this summary of state-of-the-art techniques and protocols.