Genetic & Epigenetic Alterations that Drive Leukemic Stem Cell Self-Renewal
Book Details
Format
Paperback / Softback
ISBN-10
1617283797
ISBN-13
9781617283796
Publisher
Nova Science Publishers Inc
Imprint
Nova Science Publishers Inc
Country of Manufacture
US
Country of Publication
GB
Publication Date
Jul 6th, 2011
Print length
57 Pages
Weight
100 grams
Dimensions
13.60 x 21.20 x 0.50 cms
Product Classification:
Oncology
Ksh 11,150.00
Not available
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Acute myeloid leukaemia has emerged as a paradigm for the concept of the cancer stem cell. This hypothesis presumes that the disease is maintained by a rare population of leukaemia-initiating stem cells which have acquired genetic or epigenetic changes. It is most likely that a single (epi)genetic event will not be sufficient to cause leukaemia, but that a number of sequential events are required. Similar to normal hematopoietic stem cells, both intrinsic as well as extrinsic factors that arise from the bone marrow niche, provide essential cues that regulate cell fate decisions such as leukaemic stem cell self-renewal and differentiation. This book reviews the genetic and epigenetic abnormalities that underlie the process of leukaemia transformation, and discusses which events potentially co-operate to induce leukaemia.
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