Global and African Perspectives on Lung Cancer : Integrating Infections, Genomics, and the Exposome

This book provides a comprehensive and integrated view of lung cancer, combining global evidence with African-specific perspectives.

This book provides a comprehensive and integrated view of lung cancer, combining global evidence with African-specific perspectives. It examines the epidemiology, histological subtypes, and multifactorial causes of the disease, with in-depth coverage of genomic alterations, molecular signatures, and population-specific variations in Africa. The chapters explore the combined impact of environmental exposures, tobacco smoke, air pollution, asbestos, silica, radon, and indoor pollutants and infectious agents, including viruses, bacteria, and parasites, as drivers of lung carcinogenesis. The volume also addresses the role of the exposome, chronic infections, immune modulation, and the lung microbiome in shaping disease risk, treatment response, and survival outcomes. The book also presents the advances in molecular diagnostics, biomarker discovery, precision oncology, and AI-enabled healthcare innovations alongside the influence of social determinants such as poverty, education, cultural factors, and healthcare access. With a focus on prevention, early detection, and equitable access to care, the book highlights African-led research, public health policies, and system-level solutions to reduce disparities and improve outcomes. Key Features: Offers a comprehensive integration of global evidence with African-specific perspectives on lung cancerExplores epidemiology, histological subtypes, and multifactorial causes, including environmental and infectious driversHighlights genomic alterations, molecular signatures, and population-specific variations relevant to AfricaExamines the role of the exposome, chronic infections, immune modulation, and lung microbiome in carcinogenesis and outcomesProvides evidence-based recommendations for prevention, policy, and health system strengthening This book is intended for researchers, clinicians, policymakers, and students in cancer research, molecular biology, epidemiology, public health, and related biomedical and health sciences fields, globally, with particular relevance for those engaged in advancing lung cancer research and care in Africa and other resource-constrained settings.