Gold Nanoparticles in Biomedical Applications

Functionalized gold nanoparticles (GNPs) with controlled geometrical, optical, and surface chemistry properties are the subject of intensive studies and applications in biology and medicine. The efficiency of biomedical applications of functionalized GNPs in therapy and diagnostics is determined by their intrinsic physiochemical parameters and by effective delivery of GNPs to target organs, cells, or subcellular components. This book discusses optical properties of GNPs, their applications in biological studies, analysis of data on the in vitro and in vivo biodistribution, immunological properties and toxicity of most popular GNPs. A multidisciplinary approach is incorporated throughout.

This book discusses fabrication of functionalized gold nanoparticles (GNPs) and multifunctional nanocomposites, their optical properties, and applications in biological studies. This is the very first book of its kind to comprehensively discuss published data on in vitro and in vivo biodistribution, toxicity, and uptake of GNP by mammalian cells providing a systematization of data over the GNP types and parameters, their surface functionalization, animal and cell models. As distinct from other related books, Gold Nanoparticles in Biomedical Applications discusses the immunological properties of GNPs and summarizes their applications as an antigen carrier and adjuvant in immunization for the preparation of antibodies in vivo. Although the potential of GNPs in nanobiotechnology has been recognized for the past decade, new insights into the unique properties of multifunctional nanostructures have recently emerged. With these developments in mind, this book unites ground breaking experimental data with a discussion of hybrid nanoparticle systems that combine different nanomaterials to create multifunctional structures. These novel hybrids constitute the material basis of theranostics, bringing together the advanced properties of functionalized GNPs and composites into a single multifunctional nanostructure with simultaneous diagnostic and therapeutic functions. Such nanohybrids can be physically and chemically tailored for a particular organ, disease, and patient thus making personalized medicine available.