Hematopoietic Stem Cell Transplantation

Kenneth Kaushansky and C. Glenn Begley
Preclinical Biology and Potential Clinical Utility of flt3 Ligand
Douglas E. Williams
Stem Cell Factor
Leo Lacerna, Jr., Russell Basser, C. Glenn Begley, Jeffrey Crawford, George Demetri, Craig H. Moskowitz, Guido Tricot, Andrew Weaver, William P. Sheridan, and John A. Glaspy
Cytokine Modulation of Hematopoietic Stem Cell Phenotype
Ahmad-Samer Al-Homsi and Peter J. Quesenberry
Homing and Self-Renewal of Hematopoietic Stem Cells
Anthony D. Ho, Michael Punzel, Stefan Fruehauf, Shiang Huang, and Bernhard Palsson
Requirements for Hematopoietic Stem Cell Engraftment and Graft Engineering: Role of Facilitating Cells
Michael Neipp, Christina L. Kaufman, Marianne Bergheim, Beate G. Exner, and Suzanne T. Ildstad
Ins and Outs of Hematopoietic Stem Cells: Regulation by Genes and Stromal Cells
Christa E. Müller-Sieburg and Rajeev Soni
Cell-Signaling by Adhesion Receptors in Normal and Leukemic Hematopoiesis

This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion of progenitor cells; allogeneic and autologous transplantation; cellular gene and immunotherapy; and more.
Examines key areas for treatment with HSC, including ambulatory care and monitoring, regimen-related toxicities, immunodeficiency and immunization, infection, chronic graft-versus-host and disease, secondary malignancies, and long-term quality of life.
Covering stem cell pool regulation and the complex interplay of extrinsic and intrinsic events, Hematopoietic Stem Cell Transplantation

summarizes current understanding and development of clinical allogeneic HSC transplantation

discusses the use of allogeneic transplantations with reduced conditioning regimen or mini-transplantation

considers various strategies for mobilization of HSCs from peripheral blood (PB) of normal donors

details detection of bone marrow contamination by tumor cells and removal procedures

focuses on efforts to increase the ex vivo transduction efficiency of human HSCs with retroviral vectors

explores the effects of growth factor administration and leukapheresis on PB stem cell donors

shows the impact of CD34+ cell isolation and the relevance of expansion of HSC from bone marrow for clinical use

reveals how minimal residue disease detection assays are crucial for tracking the clinical significance of infused tumor cells

employs automated fluorescence image cytometry to study early HSC behavior following seeding
Incorporating contributions from over 90 researchers who cite more than 2180 references to encourage continued study,