Histone Deacetylase Inhibitors (HDIs) : Pharmacology, Uses & Health Effects
Book Details
Format
Hardback or Cased Book
ISBN-10
1634638352
ISBN-13
9781634638357
Publisher
Nova Science Publishers Inc
Imprint
Nova Science Publishers Inc
Country of Manufacture
US
Country of Publication
GB
Publication Date
Jun 1st, 2015
Print length
95 Pages
Weight
304 grams
Dimensions
28.00 x 20.80 x 1.30 cms
Product Classification:
PharmacologyEnzymology
Ksh 28,800.00
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Histone deacetylase inhibitors (HDIs) are good anti-cancer targets. Histone acetyltransferases (HATs) and HDIs play opposite roles in the regulation of gene expression via an epigenetic mechanism. HATs catalyse the acetylation of lysine residues in histone tails, facilitating and sustaining gene transcription. HDIs remove the acetyl moieties from the epsilon-amine of lysine residues of histone tails, leading to a more condensed form of chromatin and preventing gene transcription. This book focuses on the use of HDIs for the treatment of lymphoid malignancies; myeloid malignancies; and breast cancer.
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