Horizons in Cancer Research : Volume 75

Volume 75 analyses the strategic actions taken by the UK in the fight against cancer, reviewing the key investments and funding made available in the country. Following this, the authors discuss how efficient targeting of thioredoxin with compounds and proper knowledge of their mechanism of action may be an efficacious therapeutic intervention for cancer. This compilation goes on to xplore the otologic complications secondary to radiotherapy for nasopharyngeal cancer cases to provide a clinical perspective on this issue. An extensive review of the published studies about metastatic colorectal cancer kinetics and changes of growth curves under the pressure of pharmacological treatments is presented, and variables related to tumor cell kinetics derived from radiologic evaluations are discussed. The authors propose a new post treatment cancer care involving the systemic administration of nanomolar concentrations of drag-reducing polymers that aims to avoid metastasis following cancer surgery. A study is carried out to compare the molecular mechanism of cytochrome P450 enzyme family members on breast cancer, as well as to compare the distinct biological processes with each other. This compilation closes with a guide for researchers concerning preserving the heterogeneity of breast cancer cell lines in terms of either isolation, selection or culture method models in order to understand the limitations of various methods.