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Inclusion of Pregnant and Lactating Persons in Clinical Trials : Proceedings of a Workshop

By: (Author) Board on Health Sciences Policy , (Author) and Translation Forum on Drug Discovery Development , (Author) and Medicine National Academies of Sciences Engineering , (Author) Health and Medicine Division , (Edited by) Andrew March , (Edited by) Carolyn Shore , (Edited by) Theresa Wizemann

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Format: Paperback / Softback

ISBN-10: 0309696372

ISBN-13: 9780309696371

Publisher: National Academies Press

Imprint: National Academies Press

Country of Manufacture: GB

Country of Publication: GB

Publication Date: Apr 7th, 2023

Print length: 146 Pages

Product Classification: Medicine

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Approximately 4 million pregnant people in the United States give birth annually, and 70 percent of these individuals take at least one prescription medication during their pregnancy. Yet, due to a number of historical, ethical, legal, scientific, and societal issues, pregnant and lactating persons are often excluded from clinical trials. As a result, pregnant and lactating persons are often taking drugs based on limited information about the benefits and risks to themselves and their developing or newborn baby. The National Academies Forum on Drug Discovery, Development, and Translation convened a workshop in June 2022 for stakeholders to examine the current state of evidence generation for drug products used by pregnant and lactating persons and discuss barriers and opportunities for including these populations in clinical trials. This publication summarizes the presentations and discussion of the workshop. Table of ContentsFront Matter1 Introduction2 Effects of Evidence Gaps in Clinical Treatment for Pregnant and Lactating Persons3 The Legal Landscape4 Lessons Learned5 Potential Practical Solutions for Including Pregnant and Lactating Persons in Clinical Trials6 Promising Innovative Approaches to Evidence Generation7 A Path Toward InclusionAppendix A: ReferencesAppendix B: Workshop AgendaAppendix C: Biographical Sketches of the Workshop Planning Committee, Speakers, and Staff

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