Increasing the Therapeutic Ratio of Radiotherapy
Softcover reprint of the original 1st ed. 2017
Book Details
Format
Paperback / Softback
Book Series
Cancer Drug Discovery and Development
ISBN-10
3319822012
ISBN-13
9783319822013
Edition
Softcover reprint of the original 1st ed. 2017
Publisher
Birkhauser Verlag AG
Imprint
Birkhauser Verlag AG
Country of Manufacture
GB
Country of Publication
GB
Publication Date
Jun 27th, 2018
Print length
280 Pages
Weight
468 grams
Dimensions
15.30 x 23.40 x 2.00 cms
Product Classification:
OncologyMedical microbiology & virologyMedical imaging
Ksh 23,400.00
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Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues.
Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy.
In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations.
Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection).
Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.
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