Indwelling Neural Implants : Strategies for Contending with the In Vivo Environment
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A compendium of contributions from noted experts in neuroprosthetics and tissue repair, this book addresses the impact, characterization, and mitigation of the healing of tissues that surround an implant. It describes the differences among wound healing in the CNS, PNS, subcutaneous tissue, and bone. It also examines performance issues of implanted neuroprosthetics arising from the chemical, mechanical, thermal, and electrical impact on surrounding tissue. Contributions present both in vitro and in vivo approaches to assessing wound healing response to materials and describe molecular and materials strategies for intervening in CNS wound repair and enhancing the electrical communication between electrode and surrounding tissue.
Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwelling Neural Implants: Strategies for Contending with the In Vivo Environment examines many of these challenges, paying particular attention to how the healing of tissues surrounding an implant can impact the intended use of a device. The contributions are divided into four sections
· Part one examines wound healing from the initial insertion trauma through the inflammatory and repair process, explaining how the action of healing varies throughout different areas of the body.
· Part two considers various performance issues specific to particular implant components, including those that arise from the chemical, mechanical, thermal, and electrical impact on surrounding tissues. It discusses challenges that result from chronic tissue stimulation and heat effects that occur with on-chip and telemetric processing.
· Part three presents both in vitro and in vivo approaches to assessing wound healing response to materials. It includes the contribution of the developer of a chronic hollow fiber membrane implant who explains how an in vivo model is used to assess molecular transport in brain tissue surrounding the implant.
· The final section evaluates molecular and materials strategies for intervening in CNS wound repair and enhancing the electrical communication between the electrode surface and the surrounding tissue. It also presents novel approaches to nerve regeneration and repair.
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