Interferon

Over the last half of century interferon (IFN), originally discovered as an antiviral protein, has developed from an inhibitor of viral replication to a major force in the antiviral response.

Reflections.- 1.1 Jean Linndemann: How to chase a red herring and come up with a Smallmouth Bass. - 1.2 J. Vilcek: Interferon research before BC (before cloning).- 1.3 S. Pestka: Purification and cloning of Interferon Alpha.- Interferons and their signaling pathways.- 2.1 P. Pitha and M. Kunzi: Type I Interferon: the ever unfolding story.- 2.2 G. Uze, G. Schreiber, J. Piehler and S. Pellegrini: The receptor of the type I interferon family.- 2.3 H. Young and J. Bream: IFN: Recent Advances I Understanding Regulation of Expression, Biological Functions and Clinical Application.- 2.4 A. van Boxel-Dezaire and G. Stark: Cell Type -Specific Signaling in response to Interferon gamma.- 2.5 J. Darnell: Interferon Research; Impact on understanding transcriptional control.- Recognition of pathogens, molecular mechanism of interferon beta induction.- 3.1 M. Severa and K. Fitzgerald: TLR-mediated activation of type I IFN during antiviral immine responses:fighting the battle to win the war.- 3.2 K. Onomoto, M. Yopeneyma and T. Fujita: Regulation of Antiviral Immune Response by RIG-I family of RNA helicases.- 3.3 M.Schlee, W.Barchets, V.Hornung and G.Hartmann: Beyond double stranded RNA-type I IFN induction by 3pRNA and other viral nucleic acids.- Interferon induced genes.- 4.1 G. Sen and S. Sarkar: The Interferon-Stimulated Genes: Targets of direct signaling by interferon, double -stranded RNA and viruses.- 4.2 A.Sadler and B. Williams: Structure and Function of the Protein Kinase R.- Virus defense.- 5.1 Y-M Loo and M. Gale: Viral Regulation and Evasion of the host response.- 5.2. O.Haller and F.Weber: Pathogenic Viruses: Smart Manipulators of the Interferon System.- Role of interferon in viral infection and autoimmunity.- 6.1 E. Zuniga, B. Hahm and M. Oldstone: Type I IFN during viralinfection: multiple triggers for a multifunctiona mediator.- 6.2 S. Crow: Type I FN in Systemic Lupus Erythematosus.- Subject Index