Unique in its two-fold protective function, alpha-lipoic acid has drawn unprecedented interest for its role as a coenzyme in mitochondrial energy metabolism and as an antioxidant and cell redox modulator. This book covers discoveries in the chemistry, biological action, and significance of alpha-lipoic acid in energy production and health. Section I reviews the molecular structure, biosynthesis, and characterization of lipoic acid. Section II describes metabolic aspects, human pharmacodynamics, energy production, and antioxidant activity. Section III discusses clinical aspects, treatment of metabolic syndromes, and loss of mitochondrial function with lipoic acid supplementation.

A state-of-the-science compilation, Lipoic Acid follows the history of this potent coenzyme and the latest discoveries regarding the chemistry, biological action, and significance in energy production, antioxidant activity, and health. The book is divided into three sections:

·         Section I: Discovery and Molecular Structure reviews the early studies leading to the discovery of alpha-lipoic acid and explains the molecular structure, biosynthesis, and the characterization of lipoic acid and its chemical derivatives.

·         Section II: Metabolic Aspects describes in detail the human pharmacokinetics of alpha-lipoic acid including the lipoic acid-derived dehydrogenase complexes and their roles in energy metabolism. It also explains antioxidant activity and redox modulation and how lipoic acid induces Phase II detoxification enzymes through activation of Nrf2-dependent gene expression.

·         Section III Clinical Aspects discusses enzyme deficiency disorders and the effects of lipoic acid on insulin. It defines lipoic acid influence on signaling pathways and AMP-activated kinase, and considers the therapeutic implications for treatment of metabolic syndromes and the improvement of mitochondrial function by lipoic acid supplementation.

Contributions from leading in