Mass Spectrometry of Nucleosides and Nucleic Acids
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Assembling the work of an international panel of researchers, this volume summarizes and reviews the latest developments in the field of nucleic acid research by mass spectrometry and provides a window on the next generation of analysis. It highlights the most popular ionization methods and illustrates the diverse strategies used in the characterization and sequencing of novel nucleosides and nucleotides. It also covers deoxyribonucleic acid (DNA), DNA-adducts, DNA-drug complexes, ribonucleic acid (RNA) oligomers of biomedical importance, RNA-protein complexes, and post-transcriptional modifications. The contributions presented in this volume capture the range of these advances, helping to inspire new findings and avenues of research.
Next, the contributors examine mass spectrometric application in the study of cyclic nucleotides in biochemical signal transduction. They analyze urinary modified nucleosides and explore DNA adducts. They discuss isotope labeling of DNA-mass spectrometry (ILD-MS) and examine various uses of electrospray ionization mass spectrometry (ESI-MS). The book reviews recent progress in the direct MS characterization of noncovalent nucleic acid-protein complexes, explores the interaction and ionization of guanidine-derived compounds with highly acidic biomolecules, and examines quantitative identification of nucleic acids via signature digestion products detected using mass spectrometry.
The book describes a direct-infusion ESI-MS approach that can serve as a screening technique for the presence of modified nucleosides from small RNAs. Lastly, it discusses the LC-MS/MS method for the in vitro replication studies on damage-containing DNA substrates, and concludes with an examination of the influence of metal ions on the structure and reactivity of nucleic acids.
The exciting developments in mass spectrometry technology have fueled incredible advances in our understanding of nucleic acids and their complexes. The contributions presented in this volume capture the range of these advances, helping to inspire new findings a
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