Metals and Genetics

This volume brings together investigators from diverse fields of clinical medicine, genetics, biochemistry, and chemistry to reflect on the broad implications of direct and indirect interactions of metals and genetic components.

Eulogy for Karen Wetterhahn: As an Introduction to the Session "Genetic Response to Environmental Exposure to Metals" for the Second International Symposium on Metals and Genetics.- Genetic Response to Environmental Exposure to Metals and Metal Transport.- 1. Metalloregulation of Soft Metal Resistance Pumps.- 2. Clastogenic Effects and Influence of Inorganic Arsenic on DNA-Repair in Mammalian Systems.- 3. Groundwater Arsenic Contamination and Sufferings of People in West Bengal, India and Bangladesh: Status Report Up to March, 1998.- 4. The Nature and Extent of Arsenic-Affected Drinking Water in Bangladesh.- 5. Chromium Biomonitoring: Achievements, Problems, and Future Challenges.- 6. Chelate Sensor Method for Mercury.- 7. Copper Transport and Ceruloplasmin during Lactation and Pregnancy.- Metal Carcinogenesis and Metal Caused DNA Damage.- 8. CAP43: A New Gene Induced by a Rise in Free Intracellular Ca2+ following Ni2+ Exposure.- 9. Zinc and Metallothionein in Mammalian Cell Cycle Regulation.- 10. Effect of Metal Compounds on the Function of Zinc Finger Proteins Involved in DNARepair.- 11. Chromium(III) as a Male Preconception Carcinogen in Mice.- 12. DNA Cleavage vs. Cross-Linking Using Nickel Peptides: Mechanistic Aspects.- 13. Copper-Dependent DNA Scission 197.- 14. Modulation of Glucocorticoid Signaling and Leukocyte Activation by Transition Metals.- Metals and Neurodegenerative Diseases.- 15. Reactions of Copper-Zinc Superoxide Dismutases with Hydrogen Peroxide: Possible Involvement in Familial Amyotrophic Lateral Sclerosis.- 16. Yeast Mitochondrial Iron Metabolism and the Pathophysiology of Friedreich'' Ataxia.- 17. Getting Copper into Mitochondria.- Genetics and Biochemistry of Metal-Related Diseases.- 18. The Copper-Transporting ATPase Defective in Wilson Disease.- 19. Towards the Characterization of the Wilson Disease Copper ATPase Metal Binding Domain.- 20. Molecular Genetics of Menkes Disease.- 21. Mutational Analysis of the Copper ATPase Affected in Menkes Disease.- 22. Clinicopathological and Molecular Genetic Features of Hereditary Ceruloplasmin Deficiency (Aceruloplasminemia).- 23. Copper Related Liver Disease in Young Children.- Metals and Gene Regulation.- 24. Regulation of Zinc Homeostasis in Yeast by the ZAP1 Transcriptional Activator.- 25. Embryonic Liver Degeneration and Increased Sensitivity Towards Heavy Metal and H2O2 in Mice Lacking the Metal-Responsive Transcription Factor MTF-1.- 26. The Transport and Intracellular Trafficking of Metal Ions in Yeast.- 27. Mechanisms of Copper Chaperone Proteins.- 28. Transcriptional Regulation of the Gene Encoding Mouse Metallothionein-3.- Contributors.