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Mitochondrial Replacement Techniques : Ethical, Social, and Policy Considerations

By: (Author) Board on Health Sciences Policy , (Author) Committee on the Ethical and Social Policy Considerations of Novel Techniques for Prevention of Mat , (Author) and Medicine National Academies of Sciences Engineering , (Author) Institute of Medicine , (Edited by) Anne Claiborne , (Edited by) Jeffrey Kahn , (Edited by) Rebecca English

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Ksh 10,450.00

Format: Paperback / Softback

ISBN-10: 0309388708

ISBN-13: 9780309388702

Publisher: National Academies Press

Imprint: National Academies Press

Country of Manufacture: US

Country of Publication: GB

Publication Date: Apr 17th, 2016

Print length: 200 Pages

Weight: 336 grams

Dimensions (height x width x thickness): 22.80 x 15.40 x 1.20 cms

Product Classification: Medical genetics
Diseases & disorders

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Mitochondrial replacement techniques (MRTs) are designed to prevent the transmission of mitochondrial DNA (mtDNA) diseases from mother to child. While MRTs, if effective, could satisfy a desire of women seeking to have a genetically related child without the risk of passing on mtDNA disease, the technique raises significant ethical and social issues. It would create offspring who have genetic material from two women, something never sanctioned in humans, and would create mitochondrial changes that could be heritable (in female offspring), and therefore passed on in perpetuity. The manipulation would be performed on eggs or embryos, would affect every cell of the resulting individual, and once carried out this genetic manipulation is not reversible. Mitochondrial Replacement Techniques considers the implications of manipulating mitochondrial content both in children born to women as a result of participating in these studies and in descendants of any female offspring. This study examines the ethical and social issues related to MRTs, outlines principles that would provide a framework and foundation for oversight of MRTs, and develops recommendations to inform the Food and Drug Administration's consideration of investigational new drug applications. Table of ContentsFront MatterSummary1 Introduction2 Science and Policy Context3 Do Ethical, Social, and Policy Considerations Preclude MRT?4 Regulation and Oversight of MRT in HumansAppendix A: Study ApproachAppendix B: Summary of MRT ResearchAppendix C: Biosketches of Committee Members

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