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Mitochondrial Replacement Techniques
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Mitochondrial Replacement Techniques : Ethical, Social, and Policy Considerations

by Board on Health Sciences Policy , Committee on the Ethical and Social Policy Considerations of Novel Techniques for Prevention of Mat , and Medicine National Academies of Sciences Engineering , Institute of Medicine

Book Details

Format Paperback / Softback
ISBN-10 0309388708
ISBN-13 9780309388702
Publisher National Academies Press
Imprint National Academies Press
Country of Manufacture US
Country of Publication GB
Publication Date Apr 17th, 2016
Print length 200 Pages
Weight 336 grams
Dimensions 22.80 x 15.40 x 1.20 cms
Product Classification: Medical genetics Diseases & disorders
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Mitochondrial replacement techniques (MRTs) are designed to prevent the transmission of mitochondrial DNA (mtDNA) diseases from mother to child. While MRTs, if effective, could satisfy a desire of women seeking to have a genetically related child without the risk of passing on mtDNA disease, the technique raises significant ethical and social issues. It would create offspring who have genetic material from two women, something never sanctioned in humans, and would create mitochondrial changes that could be heritable (in female offspring), and therefore passed on in perpetuity. The manipulation would be performed on eggs or embryos, would affect every cell of the resulting individual, and once carried out this genetic manipulation is not reversible. Mitochondrial Replacement Techniques considers the implications of manipulating mitochondrial content both in children born to women as a result of participating in these studies and in descendants of any female offspring. This study examines the ethical and social issues related to MRTs, outlines principles that would provide a framework and foundation for oversight of MRTs, and develops recommendations to inform the Food and Drug Administration's consideration of investigational new drug applications. Table of ContentsFront MatterSummary1 Introduction2 Science and Policy Context3 Do Ethical, Social, and Policy Considerations Preclude MRT?4 Regulation and Oversight of MRT in HumansAppendix A: Study ApproachAppendix B: Summary of MRT ResearchAppendix C: Biosketches of Committee Members

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