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By: (Edited by) Claus Svendsen , (Edited by) Cornelis A. M. van Gestel , (Edited by) Jan E. Kammenga , (Edited by) Martijs Jonker , (Edited by) Ryszard Laskowski
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Although the fields of toxicology and human health assessment address similar problems, the experts from these fields do not meet very frequently. Originating from a meeting of scientists in both fields, this book clearly links ecotoxicology and classic human toxicology. It incorporates extensive reviews of exposure to toxicants, toxicokinetics and toxicodynamics, toxicology of mixtures, and risk assessment. This unusual combination of coverage sets it apart from other ecotoxicological and risk assessment resources that do not discuss these topics in an integrated manner.
In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology and classic human toxicology, Mixture Toxicity: Linking Approaches from Ecological and Human Toxicology incorporates extensive reviews of exposure to toxicants, toxicokinetics and toxicodynamics, toxicity of mixtures, and risk assessment.
The book examines developments in both fields, compares and contrasts their current state of the art, and identifies where one field can learn from the other. Each chapter provides an essential overview of the state of the art in both human and ecotoxicological mixture risk assessment, focusing on the work published in the last fifteen years. The coverage progresses from exposure to risk assessment, at each step identifying the special complications typically raised by mixtures. Based on in-depth discussions among specialists representing different disciplines and approaches, the chapters each address:
An unusual combination of different points of view on exposure to and risk assessment of chemical mixtures, this book summarizes current knowledge on combined effects of toxicant mixtures, information that is generally only available in a very fragmented form as individual journal papers. It identifies possible crosslinks and includes recommendations for mutual developments that can improve the state of knowledge on mixture toxicity and ultimately lead to better and more integrated risk assessment.
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