Molecular Aspects of G Protein-Coupled Receptors : Interacting Proteins & Function
Book Details
Format
Hardback or Cased Book
ISBN-10
1600219152
ISBN-13
9781600219153
Publisher
Nova Science Publishers Inc
Imprint
Nova Science Publishers Inc
Country of Manufacture
US
Country of Publication
GB
Publication Date
Nov 1st, 2007
Print length
309 Pages
Weight
836 grams
Dimensions
26.20 x 18.60 x 2.50 cms
Product Classification:
Proteins
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In the recent years studies based on two-hybrid screens, proteomic, biochemical and cell biology approaches, have shown that intracellular domains of G protein-coupled receptors (GPCR) or heptaspanning membrane receptors (HSMRs) interact with intracellular proteins. These interactions are the basis of a protein network associated to these receptors which includes scaffolding proteins containing one or several PDZ (post-synaptic density-95, discs large, zona occludens-1) domains, signalling proteins and proteins of the cytoskeleton. The present book is focused on the emerging evidence for interactions of G protein-coupled receptors with scaffolding, cytoskeletal and signalling proteins that will play a role in the targeting, anchoring and functioning of these receptors in the plasma membrane, thus contributing to cell development and plasticity.
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