Nonhuman Primate Models in Biomedical Research : State of the Science and Future Needs

Nonhuman primates represent a small fraction of animals used in biomedical research, but they remain important research models due to their similarities to humans with respect to genetic makeup, anatomy, physiology, and behavior. Limitations in the availability of nonhuman primates have been exacerbated by the COVID-19 pandemic and recent restrictions on their exportation and transportation, impacting National Institutes of Health (NIH)-funded research necessary for both public health and national security. Additionally, there is continued interest in understanding whether and how nonanimal models can be used to answer scientific questions for which nonhuman primates are currently used. At the direction of the U.S. Congress, NIH asked the National Academies of Sciences, Engineering, and Medicine to convene an expert committee to conduct a landscape analysis of current and future use of nonhuman primates in NIH-supported biomedical research, as well as opportunities for new approach methodologies to complement or reduce reliance on nonhuman primate models. This report provides the committee findings and conclusions. Table of ContentsFront MatterSummary1 Introduction2 Contribution of Nonhuman Primate Models to Advances in Human Health3 Current Landscape of Use and Availability of Nonhuman Primates for NIH-Supported Biomedical Research4 The Landscape of New Approach Methodologies5 Future Needs and Opportunities for Nonhuman Primate Models in Biomedical ResearchAppendix A: Study Approach and MethodsAppendix B: Data on Nonhuman Primate Use in NIH-Supported Biomedical ResearchAppendix C: Biographical Sketches of Committee Members and StaffAppendix D: Disclosure of Unavoidable Conflicts of Interest