Oncogenes and Tumour Suppressors

Oncogenes and tumour suppressor genes are two types of genes which are involved in the regulation of the cell cycle and either cause or suppress tumour formation. This volume takes stock of some of the major developments in this critical field. An eminent team of researchers have been commissioned to summarize the current state of their particular areas of expertise.

Oncogenes and tumour suppressor genes have been the focus of much research because of their role not only in cancer but also in normal cell growth and differentiation. Oncogenes and Tumour Suppressors is a unique volume that brings together a team of leading researchers to present and critically assess our current knowledge. The book covers two major areas of interest: oncogenes and signal transduction, and tumour supressors and cell cycle control. Topics covered include the mechanisms of oncogene perturbation; growth factors and their receptors in cell transformation; oncogenic cytoplasmic protein tyrosine kinases; the RAS/RAP/ERK signal transduction pathway; oncogenic transcription factors; mammalian cell cycle control; the retinoblastoma gene product and its relatives; the tumour suppressor gene p53; tumour suppressors and the inheritance of cancer; the clinical relevance of oncogenes. Oncogenes and Tumour Suppressors is a major review work that provides an unparalleled summary of our current understanding of this field as viewed by some of its leading researchers. It is of interest to all those involved in research on the cell cycle, signal transduction, and cancer biology. The book is also an excellent reference source with over 1800 selected citations to the primary literature.