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Overview of Genetic Factors & Environmental Triggers in the Pathogenesis of Tourette's Syndrome

By: (Author) Changgui Li , (Author) Cong-Yi Wang , (Author) Ping Yang , (Author) Qian Dong , (Author) Shi-Guo Liu , (Author) Wei Wang , (Author) Zhimin Miao

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Ksh 11,150.00

Format: Paperback / Softback

ISBN-10: 1616687487

ISBN-13: 9781616687489

Publisher: Nova Science Publishers Inc

Imprint: Nova Science Publishers Inc

Country of Manufacture: US

Country of Publication: GB

Publication Date: Sep 22nd, 2010

Print length: 59 Pages

Weight: 114 grams

Dimensions (height x width x thickness): 21.40 x 13.60 x 0.70 cms

Product Classification: Neurosciences

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Tourette''s syndrome (TS) is an inheritable, childhood-onset neuropsychiatric disorder characterised by the presence of motor and phonic tics. Despite decades of extensive studies, the exact disease aetiology remains poorly understood. It is believed that susceptibility to TS is determined by the interactions of multiple genetic loci with unknown environmental factors. As a result, a great deal of research has been focused on identifying TS susceptibility genes. Thus far, at least 12 susceptibility loci have been suggested by genome-wide screenings, but none of them has been replicated probably due to genetic heterogeneity. Candidate gene approach has also suggested evidence for several genes relevant to neuronal signalling such as dopamine receptor and serotonin receptor. This book discusses the current state of genetic studies in TS susceptibility.

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