Pharmacology of GABA and Glycine Neurotransmission

Highlighting the developments and future directions in GABA and glycine research, this volume covers the major inhibitory neurotransmitters from the molecular mechanisms of signal transduction to their role in health and disease.

1. Physiology of the GABA and Glycine System. 2. The Molecular Architecture of GABA A Receptors. 3. Pharmacology and Pathophysiology of GAB A-Receptor Subtypes by Genetic Dissection. 4. Steroid Modulation of GABA A Receptors. 5. Allosteric Modulation of GABA A Receptor Function by General Anesthetics and Alcohols. 6. Anticonvulsants Acting on the GABA-System. 7. Heterologous Regulation of GABA A Receptors: Protein Phoyphorylation. 8. Tolerance and Dependence to Ligands of the Benzodiazepine Recognition Sites Expressed by GABA A Receptors. 9. GABA A Receptors and Disease. 10. GABA C Receptors: Structure, Function and Pharmacology. 11. Structure of GABA B Receptors. 12. Pharmacology of GABA B Receptors. 13. GABA B Receptor Signaling Pathways. 14. Structure and Function of GABA Transporters. 15. Pharmacology of GABA Transporters. 16. Structures, Diversity and Pharmacology of Glycine Receptors and Transporters.