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Polymorphism in the Pharmaceutical Industry : Solid Form and Drug Development

By: (Edited by) Markus von Raumer , (Edited by) Rolf Hilfiker

Publisher Out of Stock

Ksh 25,200.00

Format: Hardback or Cased Book

ISBN-10: 3527340408

ISBN-13: 9783527340408

Publisher: Wiley-VCH Verlag GmbH

Imprint: Blackwell Verlag GmbH

Country of Manufacture: DE

Country of Publication: GB

Publication Date: Feb 13th, 2019

Print length: 512 Pages

Weight: 1,120 grams

Dimensions (height x width x thickness): 25.10 x 17.70 x 2.80 cms

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"Polymorphism in the Pharmaceutical Industry - Solid Form and Drug Development" highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus on quality by design (QbD) concepts. It covers all important issues by way of case studies, ranging from properties and crystallization, via thermodynamics, analytics and theoretical modelling right up to patent issues. As such, the book underscores the importance of solid-state chemistry within chemical and pharmaceutical development. It emphasizes why solid-state issues are important, the approaches needed to avoid problems and the opportunities offered by solid-state properties. The authors include true polymorphs as well as solvates and hydrates, while providing information on physicochemical properties, crystallization thermodynamics, quantum-mechanical modelling, and up-scaling. Important analytical tools to characterize solid-state forms and to quantify mixtures are summarized, and case studies on solid-state development processes in industry are also provided. Written by acknowledged experts in the field, this is a high-quality reference for researchers, project managers and quality assurance managers in pharmaceutical, agrochemical and fine chemical companies as well as for academics and newcomers to organic solid-state chemistry.

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