Progress in Neurodegeneration : The Role of Metals
Book Details
Format
Hardback or Cased Book
ISBN-10
1607413175
ISBN-13
9781607413172
Publisher
Nova Science Publishers Inc
Imprint
Nova Science Publishers Inc
Country of Manufacture
US
Country of Publication
GB
Publication Date
Jan 5th, 2010
Print length
382 Pages
Weight
972 grams
Dimensions
26.40 x 19.30 x 3.00 cms
Product Classification:
Neurology & clinical neurophysiology
Ksh 20,900.00
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This book highlights the role of some metals which induce oxidative stress and imbalances in the neurodegenerative diseases such as Alzheimer disease, Parkinson disease, Amyotrophic Lateral Sclerosis, Huntington Disease, and other dementias. The chemistry and biochemistry of metals induced-oxidative stress, protein damage is first described, followed by the evidence for a pathological role of oxidative stress in these disease states. It is tempting to speculate that free radical oxygen chemistry contributes to pathogenesis in all these conditions, though it is as yet undetermined what types of oxidative changes occur early in the disease, and what types are secondary manifestations of neuronal degeneration. Finally the authors review different metals to describe their specific role in the different pathologies.
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