Ranking Vaccines : A Prioritization Framework: Phase I: Demonstration of Concept and a Software Blueprint

As a number of diseases emerge or reemerge thus stimulating new vaccine development opportunities to help prevent those diseases, it can be especially difficult for decision makers to know where to invest their limited resources. Therefore, it is increasingly important for decision makers to have the tools that can assist and inform their vaccine prioritization efforts. In this first phase report, the IOM offers a framework and proof of concept to account for various factors influencing vaccine prioritization-demographic, economic, health, scientific, business, programmatic, social, policy factors and public concerns. Ranking Vaccines: A Prioritization Framework describes a decision-support model and the blueprint of a software-called Strategic Multi-Attribute Ranking Tool for Vaccines or SMART Vaccines. SMART Vaccines should be of help to decision makers. SMART Vaccines Beta is not available for public use, but SMART Vaccines 1.0 is expected to be released at the end of the second phase of this study, when it will be fully operational and capable of guiding discussions about prioritizing the development and introduction of new vaccines. Table of ContentsFront MatterSummary1 Introduction: From Smallpox to SMART Vaccines2 Modeling Strategy: From Single Attribute to Multiple Attributes3 Data Evaluation and Software Development4 Observations and Looking ForwardReferencesAppendix A: Mathematical FunctionsAppendix B: Candidate Disease Profiles and DataAppendix C: Stakeholder SpeakersAppendix D: Biographical Information