Regenerative Medicine - from Protocol to Patient : 1. Biology of Tissue Regeneration

Depicted are the principles ofmolecular mechanisms controlling asymmetric cell division, stem cell differentiation,developmental and regenerative biology, epigenetic and genetic control as well asmathematical modelling for cell fate prediction.

Regenerative medicine is the main field ofgroundbreaking medical development and therapy using knowledge from developmental andstem cell biology, as well as advancedmolecular and cellular techniques. This collection of volumes on Regenerative Medicine: FromProtocol to Patient, aims to explain the scientific knowledge and emergingtechnology, as well as theclinical application in different organ systems and diseases. Internationalleading experts from all over the world describe the latest scientific andclinical knowledge of the field of regenerative medicine. The process of translatingscience of laboratory protocols into therapies is explained in sections onregulatory,ethical and industrial issues. This collection is organized into five volumes: (1) Biology ofTissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering,Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) RegenerativeTherapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientificbasis, therapeutical protocols, clinical translation and practiced therapies in regenerativemedicine. Volume 1 contains eleven chapters addressing the latest basic science knowledge on the “Biologyof Tissue Regeneration”. The principles of cell regeneration control by extracellularmatrix and the biology of stemcell niches are explained. Depicted are the principles ofmolecular mechanisms controlling asymmetric cell division, stem cell differentiation,developmental and regenerative biology, epigenetic and genetic control as well asmathematical modelling for cell fate prediction. Regenerative biology of stem cells in the central nervous and cardiovascular systems leading to complex tissueregeneration in the model species axolotl and zebrafish, as well as the impact of immune signalling on nuclear reprogramming areoutlined. These up to date accounts  gives the readers advanced insights into thebiological principles of the regenerative processes in stem cells, tissues andorganisms.