Reverse Transcriptase Inhibitors in HIV/AIDS Therapy

A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS.

Structural Studies on HIV Reverse Transcriptase Related to Drug Discovery David K. Stammers and Jingshan Ren Zidovudine, Lamivudine, and Abacavir Monica Carten and Harold Kessler Stavudine, Didanosine, and Zalcitabine Gail Skowron, Sapna Chowdhry, and Michael R. Stevens Emtricitabine Gail Skowron, Jeffrey Bratberg, and Rudi Pauwels Nucleotide Analogs Craig J. Hoesley Resistance to Nucleoside and Nucleotide Reverse Transcriptase Inhibitors Nancy Shulman and Mark Winters Pharmacokinetics of Reverse Transcriptase Inhibitors Patrick Hoggard, Stephen Kewn, Saye Khoo and David Back Peripheral Neuropathy Associated With Nucleoside Reverse Transcriptase Inhibitor Therapy Bruce A. Cohen and Russell Bartt Mitochondrial Dysfunction and Nucleoside Reverse Transcriptase Inhibitor Therapy: A Pathophysiological Perspective William Lewis Mitochondrial Toxicity and Lipodystrophy Grace McComsey Nevirapine David Asmuth and Richard Pollard Efavirenz Graeme J. Moyle and Brian Conway Delavirdine Brian Conway Resistance to Non-Nucleoside Reverse Transcriptase Inhibitors F. Ramzi Asfour and Richard Haubrich Vertical Transmission of HIV and Therapeutic Interventions Susan Cu-Uvin, Arlene Bardeguez, and Carla Chibwesha New Reverse Transcriptase Inhibitors in Development Rudi Pauwels Antiretroviral Drugs for Millions Allan Ronald, Elly Katabira, and Merle Sande Postscript Richard Ogden and Gail Skowron Index