Role of Capsaicin in Oxidative Stress and Cancer
2013 ed.
Book Details
Format
Paperback / Softback
Book Series
Diet and Cancer
ISBN-10
9401784299
ISBN-13
9789401784290
Edition
2013 ed.
Publisher
Springer
Imprint
Springer
Country of Manufacture
NL
Country of Publication
GB
Publication Date
May 19th, 2015
Print length
178 Pages
Ksh 16,200.00
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This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; involvement of mitochondrial respiratory chain in the production of ROS; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.
This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.
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