Small Interfering RNA : New Research
Book Details
Format
Hardback or Cased Book
ISBN-10
1606921584
ISBN-13
9781606921586
Publisher
Nova Science Publishers Inc
Imprint
Nova Science Publishers Inc
Country of Manufacture
US
Country of Publication
GB
Publication Date
Jan 4th, 2009
Print length
265 Pages
Weight
786 grams
Dimensions
26.40 x 18.40 x 2.40 cms
Product Classification:
Medical genetics
Ksh 31,150.00
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RNA interference is a gene silencing phenomenon triggered by dsRNA (double-stranded RNA) and has been widely used for studying gene functions. The short interfering RNA (siRNA) responsible for RNA interference varies markedly in its gene silencing efficacy. This book reviews the recently reported siRNA design guidelines and clarifies the problems concerning the guidelines. An effective method for selecting siRNA target sequences from many possible candidate sequence is also described by using Bayes'' theorem. Furthermore, the development of a durable RNAi therapy for cancer and viral infections, which may require the use of multiple inhibitors is evaluated. This book also reviews the structure, application and therapeutic challenges of siRNA.
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