Sparking Signals : Kinases as Molecular Signaltransducers and Pharmacological Drug Targets in Inflammation
1st ed. Softcover of orig. ed. 2008
Book Details
Format
Paperback / Softback
Book Series
Ernst Schering Foundation Symposium Proceedings
ISBN-10
3642092624
ISBN-13
9783642092626
Edition
1st ed. Softcover of orig. ed. 2008
Publisher
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint
Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Country of Manufacture
GB
Country of Publication
GB
Publication Date
Nov 25th, 2010
Print length
187 Pages
Weight
306 grams
Dimensions
22.80 x 15.20 x 1.40 cms
Product Classification:
ImmunologyPharmacologyPharmacologyBiochemistry
Ksh 16,200.00
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The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity.
Protein phosphorylation is an essential post-translational modification that modulates cell–cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation, and metabolism. The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. Inhibitors that target protein kinases have proven efficacious in clinical settings and their continued development is the current focus of many drug discovery groups.
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