Sperm Nuclear Maturation : A Basic & Clinical Approach
Book Details
Format
Paperback / Softback
ISBN-10
1616681942
ISBN-13
9781616681944
Publisher
Nova Science Publishers Inc
Imprint
Nova Science Publishers Inc
Country of Manufacture
US
Country of Publication
GB
Publication Date
Oct 21st, 2011
Print length
129 Pages
Weight
224 grams
Dimensions
15.30 x 22.80 x 0.90 cms
Product Classification:
DNA & Genome
Ksh 9,550.00
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In somatic cells, DNA is normally wrapped around the histones octamer to forms nucleosomes that eventually give rise to a solenoid DNA structure. Unlike somatic cells, in mammalian sperm, the development of spermatids into mature spermatozoa is accomplished by a series of structural and chemical modifications including a gradual replacement of lysine-rich histones by transition proteins and then by protamines which bind more tightly to DNA than histones, which results in compaction of chromatin in the sperm nucleus, a process which is termed ''sperm chromatin condensation''. This book examines the several techniques that have been devised in order to study chromatin and DNA defects in human spermatozoa.
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